Some ways people throughout the ages have discover ped the unknown is by accident. They go looking for other things and end up finding things that they never thought they would. Another way is just by traveling around and bumping into new and exciting things.
People have devoted their lives and time to a life of exploration and discovery because thats what they love , and they love exploring new things around the world, its like their hobby.
The sacrifices this type of devotion involves is leaving and being away from family for a long period of time, and maybe missing out on important parts of their lives.